Talk:Chloroquine

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3D molecular model[edit]

Rather than continuing the cycle of edits and reversions ([1], [2], [3], [4]), can we discuss which 3D model of the chloroquine molecule to use in the infobox?

Chloroquine 3D structure.png Chloroquine-ligand-CLQ-A-from-PDB-xtal-4FGL-Mercury-3D-balls.png Chloroquine-ligand-CLQ-A-from-PDB-xtal-4FGL-Mercury-3D-spacefill.png
Image A Image B Image C

Image A was added to the article in March ([5]) and while it looks great, it is not clear where the structural information comes from. That being the case, I created images B and C based on experimental data. The structure is based on an X-ray crystallographic study reported in J. Biol. Chem. (2013) 288, 11242-11251. The data is freely available from PDB entry 4FGL and PDB ligand entry CLQ. Complete citations to the scientific literature are provided on the image description page, alongside a note that entry CDMQUI in the Cambridge Structural Database corroborates the key structural features in the image.

The choice of ball-and-stick model or space-filling model is a judgement call, but to my eyes it's much easier to see all the atoms and the overall shape in Image B. Space-filling images A and C are best reserved for depicting scenarios like the one in File:Cucurbit-6-uril ActaCrystallB-Stru 1984 382.jpg where the volume the molecule occupies matters.

BaptisteGrandGrand (talk · contribs), can you tell us the source of the structure shown in File:Chloroquine 3D structure.png? Then we can decide which image has the stronger scientific basis and therefore which one should be used in the article.

Ben (talk) 17:54, 16 May 2020 (UTC)

References

  • Image B is preferable and I have seen no reason for preferring A. Thincat (talk) 13:11, 27 May 2020 (UTC)

I am surprised that this important paper from the CDC Special Pathogens Branch is not included: Martin J Vincent, Eric Bergeron, Suzanne Benjannet, Bobbie R Erickson, Pierre E Rollin, Thomas G Ksiazek, Nabil G Seidah, Stuart T Nichol: Chloroquine is a potent inhibitor of SARS coronavirus infection and spread. Virol J. 2005 Aug 22;2:69[edit]

I am surprised that this important paper from the CDC Special Pathogens Branch is not included: Martin J Vincent, Eric Bergeron, Suzanne Benjannet, Bobbie R Erickson, Pierre E Rollin, Thomas G Ksiazek, Nabil G Seidah, Stuart T Nichol: Chloroquine is a potent inhibitor of SARS coronavirus infection and spread. Virol J. 2005 Aug 22;2:69 ZachWurst (talk) 16:13, 1 August 2020 (UTC)

Zinc ionosphere[edit]

While Chloroquine has not been found of value in treating Covid directly, it been described as valuable in carrying zinc into cells thus slowing the reproduction of Covid 19 virus. We need an intermediate step of therapeutic treatment before a vaccine is made available. Perhaps, someone could expand on chloroquine and hydroxychloroquine in that role.Longinus876 (talk) 09:51, 12 August 2020 (UTC)