Talk:Philadelphia chromosome

Medicine: Hematology-oncology / Genetics Mid‑importance

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Molecular Biology: MCB B‑class

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New pictures[edit]

I've no idea how to edit wikipdeia but someone has inserted random words into this page (ie, balls and penis) could someone fix it. or revert.

I added these pictures, but they probably need re-placement, wherever you think. rhyax 23:51, 5 Sep 2004 (UTC)

This is beautiful. I wish I had firsthand access to these pictures :-). JFW | T@lk 00:47, 6 Sep 2004 (UTC)

It would be a good idea to enlarge the picture a little bit. The picture itself is of pretty good quality and provides a helpful representation of the subject, good job! Anonymous, Dec 2006.

Merge from Bcr-abl fusion protein[edit]

I think the Bcr-abl fusion protein is better explained by this article than that one alone, so it should be redirected. Mikael Häggström (talk) 14:59, 24 June 2010 (UTC)[reply]

I agree. As this is an old discussion, I am implementing this merge.

Word choice, precision and readability[edit]

I made some changes to the wording on the molecular biology of BCR-Abl:

"The fused BCR-Abl protein interacts with the interleukin-3 receptor beta(c) subunit. The ABL tyrosine kinase activity of BCR-Abl is elevated relative to wild-type ABL. Since ABL activates a number of cell cycle-controlling proteins and enzymes, the result of the BCR-Abl fusion is to speed up cell division. Moreover, it inhibits DNA repair, causing genomic instability and potentially causing the feared blast crisis in CML."

Incorrect spelling in schematic picture[edit]

The "e" is missing in the word "chromosome" in the schematic picture. Norman21 (talk) 11:21, 25 December 2012 (UTC)[reply]

Also, the schematic picture identifies the genes as abl and bcl, and although the lowercase letters are poor style, it's even worse style because it's actually BCR (Breakpoint Cluster Region) not BCL. (BCL, or B-cell lymphoma happens to be something else cancer related)

History[edit]

Just passing through, and will come back with references, but I highly doubt that Peter Nowell was 'surprised' to see condensed (distinct) chromosomes in a mitotic (dividing) cell. The human karyotype had been defined by the mid-fifties, and the techniques necessary for observing it started to be developed well before that. 72.90.93.234 (talk) 11:55, 30 March 2017 (UTC)[reply]