Talk:Phenylthiocarbamide

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Factual Error[edit]

Hi, I don't know how to edit things on Wikipedia but someone made a mistake in this article. The line with reference ONE about growing transparent fish is true, but not for PTC. The compound is called PTU- check the reference. If anyone could fix this I would appreciate it. I just happened to be on this page and I use PTU on fish (I have a neurobiology graduate student in a zebrafish lab) and happened to have noticed the mistake!

Thanks!

There is no mistake. Phenylthiocarbamide (PTC) and phenylthiourea (PTU) are synonyms.

Untitled[edit]

Does anyone know of any side effects or adverse reactions to this chemical?

It is carcinogenic according to my bioloy teacher, but I don't know to what degree. By the way, the link out is broken, but I don't want to change it until someone gets another.Eriathwen 20:17, Mar 18, 2005 (UTC)

The MSDS suggests that it is very toxic. However, the LD50 is pretty high (5mg/kg rat). I don't think the tasting papers used in classroom demonstrations can be considered dangerous, but you shouldn't be eating a lot of it. The MSDS specifically says about cancer: "CARCINOGENIC EFFECTS: Not available." --Mdwyer 22:48, 12 July 2006 (UTC)[reply]

Extremely hazardous in case of ingestion. Very hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. Hazardous in case of skin contact (permeator). Corrosive to eyes and skin. The amount of tissue damage depends on length of contact. Eye contact can result in corneal damage or blindness. Skin contact can produce inflammation and blistering. Inhalation of dust will produce irritation to gastro-intestinal or respiratory tract, characterized by burning, sneezing and coughing. Severe over-exposure can produce lung damage, choking, unconsciousness or death. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering.

MSDSs aren't very helpful in these circumstances because they're almost always regarding the concentrated form of the chemical. I wouldn't be surprised if PTC crystals are irritating, but what about a 0.003% working solution? 192.87.37.12 (talk) 13:29, 17 August 2012 (UTC) Eirinn[reply]

I don't know if it has any side effects or not. Can anyone tell me what compounds PTC may be found in? This example of "taster" versus "nontaster" is used as an example in genetic inheritance frequently, so does that mean that it is something that we might encounter in our daily lives? Thanks for your unput. God bless!

Some people believe that PTC is found in cilantro, but the people who hate cilantro aren't necessarily the same people who think the taste of PTC is vile. --Mdwyer 22:48, 12 July 2006 (UTC)[reply]

SMILES[edit]

In case this compound ever gets a chemical infobox, the SMILES notation for it is "S=C(N)Nc1ccccc1". Catbar (Brian Rock) 02:13, 25 August 2006 (UTC)[reply]

New Research linking Broccoli with PTC[edit]

I can remove the Cilantro reference, and replace it with broccoli! First, I want to find the orignal document to cite, though. Here's the article and some snippets, in case the link goes bad. --Mdwyer 01:20, 27 September 2006 (UTC)[reply]

The original paper is doi:10.1016/j.cub.2006.08.049. Definitely worth a cite. —Keenan Pepper 02:25, 30 September 2006 (UTC)[reply]

Oh, thank you! Sadly, I no longer have ready access to a research library, and I'm not quite ready to spend $30usd on the article. I'd like to read the original study before writing anything up. It seems wrong to cite a study I haven't read. --Mdwyer 05:41, 30 September 2006 (UTC)[reply]

I have access to it through my university, and I think I'm allowed to email you a copy of it. Just don't go distributing it willy-nilly. —Keenan Pepper 05:46, 30 September 2006 (UTC)[reply]

http://www.economist.com/science/PrinterFriendly.cfm?story_id=7941707 Current Biology, Mari Sandell and Paul Breslin, of the Monell Chemical Senses Centre, in Philadelphia 21 Sep 2006

hTAS2R38. The protein derived from this gene is known, from laboratory experiments, to be sensitive to a substance called phenylthiocarbamide (PTC). This compound contains a molecular group called thiourea. And thiourea-containing substances are known from other studies to inhibit the function of the thyroid gland. Cruciferous vegetables, such as watercress, turnips and—most pertinently—broccoli, are rich in a group of thiourea-containing compounds called glucosinolates.

All volunteers found the non-cruciferous vegetables equally bitter, but their reactions to the cruciferous ones depended on their genes. Those with two copies of the version of hTAS2R38 coding for the protein that binds best to PTC (one copy having been inherited from each parent) thought broccoli and its cousins the most bitter. Those who had two copies of the poorly binding version thought they tasted fine. Those with one of each had an intermediate reaction.

Tongue rolling[edit]

Hi, I have a memory of the ability to roll the tongue being linked with the ability to taste PTC; can anyone provide any further information on this? Rob.desbois 10:28, 7 July 2007 (UTC)[reply]

BY:BOB —Preceding unsigned comment added by 96.231.158.71 (talk) 23:56, 29 January 2008 (UTC)[reply]

bad wording[edit]

The statement "test to determine PTC sensitivity is one of the most commonly used[citation needed] genetic tests on humans." is at least badly worded. It is a taste test not a genetic test. The results can be tied back to the genes but it is not a "genetic" test any more than eye colour is. It is a nice binary test, yes or no with little chance of it becoming a racist criteria.

How about sneezing in bright sun, tongue rolling, shape of nose, etc. etc.

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What is PTC?[edit]

This article does very little at explaining how and why PTC is used. Before focusing on the genetic ability to taste this substance, we should at least have some information on how PTC came to prominence. —Preceding unsigned comment added by Teimu.tm (talk • contribs) 17:46, 9 May 2009 (UTC)[reply]

Answering this qustion eight years too late: PTC isn't "used". It's a substance which occurs naturally in some foodstuffs. It "came to prominence" when it was found that the ability to taste it varies greatly. Maproom (talk) 22:57, 17 September 2017 (UTC) Pinging Teimu.tm. Maproom (talk) 22:59, 17 September 2017 (UTC)[reply]

References[edit]

I've put the journal references inline, but removed one because the journal has no online presence (not even listed on Medline).

Kameswaran L, Gopalakrishnan S, Sukumar M (1974). "Phenylthiocarbamide and naringin taste threshold in South Indian medical students". Ind J Pharmac. 6 (3): 134–140.{{cite journal}}: CS1 maint: multiple names: authors list (link)

I cannot read the article or find reference to it elsewhere and it is not clear why the article is being cited, because the original editor who added the article has not put a reference in the text. If anyone can find a copy of this article and thinks it is worth putting back as an inline citation then please be my guest.--Gak (talk) 06:11, 5 December 2009 (UTC)[reply]

Merge / redirect PTC tasting to here[edit]

I think PTC tasting should be merged or redirected to here. It seems like it is a related topic, but I don't personally know too much about chemistry or genetics. Can someone provide some input on a possible merger? Thanks, Natg 19 (talk) 21:29, 18 May 2015 (UTC)[reply]

This article is primary genetically and and physiologically, but Phenylthiocarbamide is in the category of chemistry, exclusively.

Yahadzija (talk) 10:36, 19 May 2015 (UTC)[reply]

Closing, given no support for the merge; I note that summary/main is a common format. Klbrain (talk) 21:13, 17 September 2017 (UTC)[reply]

PTC and evolution[edit]

The evolutionary aspect of PTC tasting is missing from this article. Is there any knowledge of how PTC tasting or lack thereof impacts evolutionary fitness? I mean, any genetically determined trait which is significant in a population is or was fitness-enhancing or is inextricably linked to a trait that is or was fitness enhancing. What is the story with PTC tasting? PAR (talk) 14:18, 21 August 2016 (UTC)[reply]